Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous- violaceous. Tumid lupus erythematosus (TLE), also known as lupus erythematosus tumidus, is a highly photosensitive form of cutaneous lupus erythematosus (cutaneous. MalaCards based summary: Lupus Erythematosus Tumidus, also known as intermittent cutaneous lupus, is related to lupus erythematosus and discoid lupus .
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Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition.
This case exemplifies the need for complete disease characterization, evidence-based treatment, and a multidisciplinary approach. In contrast to SCLE and DLE, 30 tumidua, 323347 follicular hyperkeratosis, epidermal atrophy, vacuolar degeneration, and thickening of the basement membrane zone usually are not found.
Tumid lupus erythematosus
The disease fills the diagnostic criteria for lupus tumidus proposed by Kuhn, which justifies the controversy in the medical literature that question whether Jessner is a lupus tumidus variant or if it is an autonomous entity. She complained of mild pruritis and tenderness.
In a few cases, there is a tendency of the skin lesions to coalesce in the periphery, producing a gyrate configuration, and erythematous, annular lesions develop on the cheeks and upper extremities of some patients, imitating the annular type of SCLE.
The clinical importance of this edematous, nonscarring, photosensitive type of CCLE as a distinct subset has been tkmidus in the literature and, since it ,upus not always been considered as a separate entity, we suggest criteria to differentiate LET from PLE, Jessner’s lymphocytic infiltration of the skin, reticular erythematous mucinosis REMpseudolymphoma, SCLE, and other variants of CCLE.
They involve sun-exposed areas eg, face, upper back, V area of the neck, extensor aspects of the arms, and shoulders ; spare the knuckles, inner aspect of the arms, and axillae; and have never been detected below the waist Figure 2.
Interestingly, the mainstay of treatment for LET, in the limited case reports and series that exist, is with antimalarial drugs, which our patient had already been taking for SLE.
Consent for publication was obtained by our patient. Laboratory abnormalities or substantial ocular toxic effects caused by antimalarials did not occur in any of the patients with LET. Lupus erythematosus tumidus—a neglected subset of cutaneous Lupus erythematosus: Active and tumieus disease luppus lead to social isolation and depression.
Tumid lupus erythematosus – Wikipedia
Further immunosuppression will inevitably lead to a higher risk of infection and considering her age, there is a high probability of developing a serious infection in her lifetime. The main difference between the diseases is the clinical manifestation.
Create a free personal account to download free article PDFs, sign up lpuus alerts, and more. If you have any concerns with your skin or its treatment, see a dermatologist for advice.
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Lupus Erythematosus Tumidus: A Unique Disease Entity
Circulating autoantibodies and tjmidus complexes are due to loss of normal immune tolerance and are pathogenic. Systemic corticosteroids or immunosuppressants were only temporarily necessary in 2 patients. National Center for Biotechnology InformationU. Cutaneous Manifestations of Rheumatic Diseases.
Cutaneous lupus erythematosus
One-third of cases are due to previous drug exposure. It may be accompanied by antiphospholipid syndrome. Cigarette smokers who have LET may not respond very well to chloroquine.
Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression. Although the patients are clinically identified by a characteristic type of skin lesion, LET has been reported previously in the literature in only a few cases. Colagenoses e a Dermatologia.
Direct immunofluorescence examination of biopsy specimens from lesional skin was performed in 5 patients following a standard technique.
The aim of treatment for cutaneous LE is to prevent flares, improve appearance and to prevent scarring. This cutaneous condition article is a stub. Bianca Pinheiro Bousquet Muylaert, R.
Young women are most often affected, and there is no restriction to race or age. Sign in to tumidys a comment Sign in to your personal account. The eruption had been present for one week and had occurred several months ago for a similar duration and had resolved without treatment or scarring. Since then, several attempts have been made to improve on this system or to provide altogether new approaches for the classification of cutaneous LE.
Test areas were evaluated until specific lesions appeared for up to 4 weeks after the last irradiation. Articles which use infobox templates with no data rows Infobox medical condition new All stub articles. The clinical criteria is met with the presence of erythematosus, thick plates with a smooth and edematous surface on sun-exposed areas that leave no scar after regression. Create a free personal account to access your subscriptions, sign up for alerts, and more.
In contrast, Kind and Goerz 15 have reported a rare but possible systemic involvement in patients with LET, but no specific manifestations have been documented. Histologic features include perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. Treatment consisted of oral prednisone, chloroquine, and topic hydrocortisone lotion. This, however, places our patient at risk for adverse drug reactions such as retinopathy or agranulocytosis with hydroxychloroquine therapy.
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Chloroquine phosphate was successfully used in a daily dose of 3. In summary, LET presents a rare, but distinct, subset of CCLE with characteristic clinical features requiring correlation with histological, photobiological, and laboratory findings, since, taken in isolation, other diagnoses can be indicated.
These questions and problems exemplify the need for further evidence-based treatments and the development of an algorithmic approach to treatment. Sign in to access your subscriptions Sign in to your personal account. There are few lupue pharmacologic treatments for LET beyond case reports and series. Abstract Lupus tumidus is considered a rare subtype of chronic cutaneous lupus erythematosus, characterized by erythema and bright urticarial erythematous-violaceous lesions that leave no scars after regression.
Chronic cutaneous lupus erythematosus. With this assay technique, serum ANA titers of greater than 1: