and pharmacological properties of Kigelia africana (Lam.) Balmkheera, Isopinnatal, Kigelin, Chemical constituents, Medicinal properties. Objective: Kigelia africana, a tropical tree, which has long been used in African . Analytical grade solvents (Fischer chemicals) were used for isolation and. cancer with drugs (pharmacotherapy) or with chemical compounds ( chemotherapy) in family comprises 21 species, of which Kigelia africana. (Lam. ) Benth is.

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The tree grows on riverbanks, wet areas along streams and on flood plains of Nigeria, Cameroon, Kenya, Guinea and Senegal.

Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts

Analysis of tocopherols by capillary supercritical fluid chromatography and mass spectrometry. Although an excess of Reactive Oxygen Species, ROS oxidative stress can result in non-controlled oxidation and damage of cellular structures such as DNA, protein and membrane lipids.

The long-term treatment of male Sprague-Dawley rats with Kigelia pinnata fruit extract was observed to ameliorates the testicular toxicity after the administration cisplatin a cytotoxic drug Azu et al. Minecoside and verminoside, two new iridoid glucosides from Veronica officinalis L. The result is as shown in Table 1 Tab.

We hereby report for the first time the major component of the oil from the root of Kigelia pinnata to be elaidic acid Isolation and structure of two new dihydroisocoumarins from Kigelia pinnata.

Inhibition of activator protein-1, nf-k b, and mapks and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J Nat Prod ; The biological importance and toxicity of elaidic acid, a trans fatty acid have remained controversial. Tannins are generally known to be useful in the treatment of inflamed or ulcerated tissues and have remarkable activity in cancer prevention Ruch et al.


The MS data are in agreement with literature data Golovnya et al. The extract was decanted, filtered and concentrated under reduced pressure using rotary evaporator to afford mg of a yellow oil which was coded KPRH.

Fractions with similar TLC profile were combined and concentrated using the rotary evaporator. Free radical scavenging activities total and relative antioxidant activities The in vitro antioxidant activities of the plant extracts Figure 5 Fig.

The spectrum was carefully compare to phytol 1 H NMR spectrum with the main difference in the presence of extra allylic proton shift at 5. The extract was found effective when tested against melanoma cells a tumour of pigmented skin cells by inhibiting the growth of cultured melanoma cells significantly Houghton et al. Helvetica Chimica Acta, Alkaloids have been associated with medicinal uses for centuries and one of their common biological properties is their cytotoxicity Nobori et al.

The plant is endemic in the south, central and West Africa Burkill, ; Olatunji and Atolani, Preparation of extract The scheme for the extraction is shown in Figure 1 Fig. In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines.

The presence of phytol in brown and blue-green algae chemivals its relationship to evolution. Determination of total phenolic composition The amount of phenolic compound in the root extracts of Kigelia pinnata was determined with Folin Ciocalteu reagent using the method of Ebrahimzadeh et al.

The hexanes extract caused inhibition of the opportunistic yeast; Cryptococcus neoformans Pinh. It is due to the presence of high content of phenolics, which could be the most effective african protecting the body against various oxidative stressors. Aqueous extract of the bark of Kigelia africana reverses early testicular damage induced by methanol extract of Carica papaya.


Niger J Nat Prod Med;1: It is predicted that compound IV may be a precursor to the biosynthesis of phytol. Johnson I, Kigeoia G, editors.

Though the plant is highly regarded for its unique medicinal potencies due to the presence of lapachol, squalene, naphthoquinones etc, the content of elaidic acid content in the oil chemicaals for caution in the use of the plant in traditional medical therapy.

Phenylpropanoid and phenylethanoid derivatives from Kigelia pinnata D.

Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts

Effects of Anacardium occidentale stem bark extract on in vivoinflammatory models. How to cite this article: The entire oil composition can be summarised as Special attention may have to be paid to the extraction method.

Advanced Search Users Online: Combined fractions 7 chemixals 17 was subjected to another silica gel column chromatography to obtain waxy constituent which was re-crystallized to give hentriacontane I. The residual plant material was further extracted with ethyl acetate to afford Iridoids from Kigelia pinnata DC. Analysis of oil fraction: National Center for Biotechnology InformationU. Other activities of lapachol and its derivatives include the prevention against Schistosoma mansoni cercarial skin penetration, Biomphalaria glabrata infection as well as forestalling embryo alteration in rats Maganha et al.